Journal: Science translational medicine
Article Title: Advances toward transformative therapies for tendon diseases
doi: 10.1126/scitranslmed.abl8814
Figure Lengend Snippet: Current therapies in clinical use for tendon diseases. Examples of products of a given therapeutic modality and mechanism of action are provided. GCR, Glucocorticoid Receptor.
Article Snippet: Therapeutic modality Molecular/biological mechanism of action Product Company Launch Chemical drug NSAID/anti-inflammatory, analgesic Indocin (indomethacin) GSK 1965 Mesulid (nimesulide) Boehringer Ingelheim, GSK, Merck, Pfizer 1985 Aulin (nimesulide) Sanofi 1990 Duraprox (oxaprozin) Aventis 2002 Felbinac (felbinac) Toko Pharmaceutical Industrial 2018 Chemical drug Corticosteroid/anti-inflammatory, analgesic Kenalog (triamcinolone acetonide) Apothecon 1978 Chemical drug Cox-2 inhibitor/anti-inflammatory, analgesic Celebrex (celecoxib) Astella Pharma 2009 Chemical drug GCR agonist/anti-inflammatory, analgesic Lederlon (triamcinolone hexacetonide) Esteve 2001 Lederspan (triamcinolone hexacetonide) Mylan Biological product PRP Not specified/tissue regeneration Terumo BCT (PRP) Terumo 2010 Cell therapy Not specified/tissue regeneration Ortho-ATI (autologous tendon cells) Johnson & Johnson, Orthocell 2010 Biomaterial Not specified/viscosupplement CartiZol (atelocollagen) Sewon Cellontech 2007 Ostenil (hyaluronan) TRB Chemedica 2012 OrthoVisc (hyaluronan) Anika Therapeutics 2016 Open in a separate window Current therapies in clinical use for tendon diseases.
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